Polymorphism of alpha-1-antitrypsin and association of S and Z alleles with duodenal ulcers
نویسندگان
چکیده
منابع مشابه
Polymorphism of alpha-1-antitrypsin and association of S and Z alleles with duodenal ulcers
Background: Duodenal ulcers are mucosal erosions that penetrate into the muscularis propria of the duodenum. They are a result of an imbalance between aggressive and defensive factors. Various environmental factors like Helicobacter pylori infection, addictions to smoking and alcohol etc. and genetic factors have been reported to be associated with duodenal ulceration. Alpha-1-antitrypsin was s...
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INTRODUCTION Inherited alpha-1 antitrypsin (AAT) deficiency is one of the three most common genetic disorders in Caucasians. It considerably increases the risk of progressive obstructive lung diseases, mostly chronic obstructive pulmonary disease. It has also been suggested that AAT deficiency might be instrumental vasculitis associated with the anti-neutrophil cytoplasm antibodies (cANCA) and ...
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BACKGROUND AND PURPOSE A possible association has been proposed for the formation of intracranial aneurysm (IA) and deficiency alleles (S and Z) of the alpha1-antitrypsin (AAT) gene. We extensively screened this gene in Japanese and Korean patients with aneurysmal subarachnoid hemorrhage. METHODS Seven allelic variants, including S and Z alleles, were genotyped by direct sequencing of genomic...
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ژورنال
عنوان ژورنال: Indian Journal of Human Genetics
سال: 2005
ISSN: 0971-6866
DOI: 10.4103/0971-6866.16290